6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide

Base Information

• Chemical Name: 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide
• CAS No.: 1345840-60-9
• Molecular Formula: C₁₂H₁₄N₄OS
• Molecular Weight: 262.335

Synonyms:6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide

Chemical Property of 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide

Chemical Property:

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Technology Process of 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide

There total 2 articles about 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione (123043-88-9,33458-26-3) → 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (1345840-60-9)

Guidance literature:

With hydrazine hydrate monohydrate; In ethanol; for 5h; Reflux;

Reference yield:

benzaldehyde (100-52-7) → 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (1345840-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: calcium chloride / ethanol / 2 h / Reflux

2: sulfuric acid; hydrazine hydrate / ethanol / 3 h / 75 °C

With sulfuric acid; hydrazine hydrate; calcium chloride; In ethanol; 1: Biginelli reaction;

DOI:10.1016/j.ejmech.2011.09.023

Reference yield: 79.0%

bromocyane (506-68-3) + 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (1345840-60-9) → 5-(5-amino-1,3,4-oxadiazol-2-yl)-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-thione (1384978-85-1)

Guidance literature:

With sodium hydrogencarbonate; In ethanol;

DOI:10.1016/j.cclet.2012.05.004

upstream raw materials:

5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione

benzaldehyde

Downstream raw materials:

5-fluoro-3-{[5-(6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one

5-iodo-3-{[5-(6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one

5-chloro-3-{[5-(6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one

3-{[5-(6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-yl]imino}-1,3-dihydro-2H-indol-2-one

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