ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate

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Chemical Name:ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate
CAS No.:1261080-70-9
Molecular Formula:C₁₉H₁₅N₃O₄S₂
Molecular Weight:413.478
Hs Code.:

Synonyms:ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate

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Chemical Property of ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate

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Technology Process of ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate

There total 5 articles about ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 41731-83-3
ethyl 2-bromo-1,3-thiazole-5-carboxylate

: 942919-24-6
1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo-[2,3-b]pyridine

: 1261080-70-9
ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.11.080

Reference yield:

: 271-63-6
7-Azaindole

: 1261080-70-9
ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane / 20 °C

2.1: tetramethylammonium bromide; Methanesulfonic anhydride / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; potassium acetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; potassium acetate; tetramethylammonium bromide; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; Methanesulfonic anhydride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil; 5.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.11.080

Reference yield:

: 889939-25-7
1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine

: 1261080-70-9
ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; potassium acetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; potassium acetate; potassium carbonate; In N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.11.080