1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one

Base Information

Chemical Name:1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one
CAS No.:1433193-90-8
Molecular Formula:C₃₂H₂₆ClN₃O₂
Molecular Weight:520.03
Hs Code.:

Synonyms:1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one

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Chemical Property of 1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one

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Technology Process of 1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one

There total 11 articles about 1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1433193-95-3
1-{2-[1-benzyl-5-(2-chlorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-4-yl]phenyl}-3-(4-methoxyphenyl)urea

: 1433193-90-8
1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one

Guidance literature:: With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 6h;
DOI:10.1016/j.tet.2013.04.039

Reference yield:

: 23583-21-3
ethyl-3-benzylamino propionate

: 1433193-90-8
1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2.1: sodium hydride; ethanol / 0 - 20 °C

3.1: water / acetonitrile / 3.5 h / Reflux

4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 1 h / Reflux

6.1: bromine / tetrachloromethane / 0.17 h / 0 °C

6.2: 0.33 h / 0 °C

7.1: triethylamine / dichloromethane / 0 - 20 °C

8.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,4-dioxane / 1 h / Reflux

9.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C

10.1: dmap / dichloromethane / 2 h / 20 °C

11.1: carbon tetrabromide; triethylamine; triphenylphosphine / dichloromethane / 6 h / 0 - 20 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; ethanol; carbon tetrabromide; water; bromine; sodium hydride; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2013.04.039

Reference yield:

: 182559-62-2
ethyl 3-[benzyl(3-ethoxy-3-oxopropyl)amino]-3-oxopropanoate

: 1433193-90-8
1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride; ethanol / 0 - 20 °C

2.1: water / acetonitrile / 3.5 h / Reflux

3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 1 h / Reflux

5.1: bromine / tetrachloromethane / 0.17 h / 0 °C

5.2: 0.33 h / 0 °C

6.1: triethylamine / dichloromethane / 0 - 20 °C

7.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,4-dioxane / 1 h / Reflux

8.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C

9.1: dmap / dichloromethane / 2 h / 20 °C

10.1: carbon tetrabromide; triethylamine; triphenylphosphine / dichloromethane / 6 h / 0 - 20 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; ethanol; carbon tetrabromide; water; bromine; sodium hydride; sodium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2013.04.039