(2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

Base Information

Chemical Name:(2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester
CAS No.:916991-68-9
Molecular Formula:C₄₈H₇₄O₆SSi₂
Molecular Weight:835.349
Hs Code.:

(2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

Synonyms:(2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

Suppliers and Price of (2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

There total 8 articles about (2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 910046-62-7
(3R,5S)-3-(tert-butyldiphenylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-oxoheptanethioic acid S-tert-butyl ester

: tert-butyldimethyl[4-methyl-3-(tributylstannanylmethyl)pent-3-enyloxy]silane

: 916991-68-9
(2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

Guidance literature:: With dimethylaluminum chloride; In toluene; at -78 ℃; for 1.5h;
DOI:10.1016/j.tetlet.2006.09.094

Reference yield:

: 910046-77-4
3-(tert-butyl-diphenyl-silanyloxy)-7,8-dihydroxy-5-(4-methoxy-benzyloxy)-octanethioic acid S-tert-butyl ester

: 916991-68-9
(2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 991 mg / Pb(OAc)4 / benzene / 1 h / 20 °C

2: 86 percent / Me₂AlCl / toluene / 1.5 h / -78 °C

With lead(IV) acetate; dimethylaluminum chloride; In toluene; benzene;
DOI:10.1016/j.tetlet.2006.09.094

Reference yield:

: 910046-60-5
(3R,5S)-3-hydroxy-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

: 916991-68-9
(2R,4S,7S)-11-(tert-butyldimethylsilanyloxy)-3-(tert-butyldiphenylsilanyloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-8,8-dimethyl-9-methyleneundecanethioic acid S-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / imidazole / dimethylformamide / 24 h / 20 °C

2: 4-methylmorpholine-N-oxide; OsO₄ / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 14 h / 20 °C

3: 991 mg / Pb(OAc)4 / benzene / 1 h / 20 °C

4: 86 percent / Me₂AlCl / toluene / 1.5 h / -78 °C

With 1H-imidazole; lead(IV) acetate; osmium(VIII) oxide; dimethylaluminum chloride; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
DOI:10.1016/j.tetlet.2006.09.094