[(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine

Base Information

Chemical Name:[(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine
CAS No.:219943-44-9
Molecular Formula:C₃₂H₂₉BrN₂O₂
Molecular Weight:553.498
Hs Code.:

Synonyms:[(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine

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Chemical Property of [(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine

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Technology Process of [(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine

There total 8 articles about [(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: (S)-1-(4-Bromo-1H-indol-3-yl)-3-methoxymethoxy-2-(9-phenyl-9H-fluoren-9-ylamino)-propan-1-ol

: 219943-44-9
[(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 ℃; for 72h;
DOI:10.1021/jo981723s

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 219943-44-9
[(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 31.0 g / pyridinium bromide perbromide / pyridine / 0.25 h / 0 °C

2: Et₃N, DMAP / tetrahydrofuran / 14 h

3: 1.) n-BuLi / 1.) THF, -78 deg C, 90 min, 2.) THF, -75 deg C, 4 h

4: 99 percent / NaOMe / tetrahydrofuran / 1 h / Ambient temperature

5: 91 percent / DMAO, BH₃*THF / tetrahydrofuran / 72 h / 0 °C

With dmap; n-butyllithium; borane-THF; sodium methylate; pyridinium hydrobromide perbromide; triethylamine; In tetrahydrofuran; pyridine;
DOI:10.1021/jo981723s

Reference yield:

: 122213-51-8
N-(9-phenylfluoren-9-yl)-L-serine isoxazolidide

: 219943-44-9
[(R)-2-(4-Bromo-1H-indol-3-yl)-1-methoxymethoxymethyl-ethyl]-(9-phenyl-9H-fluoren-9-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / DIEA / CH₂Cl₂ / 20 h / Ambient temperature

2: 96 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

3: 1.) n-BuLi / 1.) THF, -78 deg C, 90 min, 2.) THF, -75 deg C, 4 h

4: 99 percent / NaOMe / tetrahydrofuran / 1 h / Ambient temperature

5: 91 percent / DMAO, BH₃*THF / tetrahydrofuran / 72 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; borane-THF; sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo981723s