4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester

Base Information

Chemical Name:4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester
CAS No.:808112-81-4
Molecular Formula:C₃₇H₆₅N₄O₉P
Molecular Weight:740.918
Hs Code.:

4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester

Synonyms:4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester

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Chemical Property of 4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester

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Technology Process of 4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester

There total 5 articles about 4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 15205-62-6
tri(tert-butyl)phosphite

: 808112-80-3
4-benzyloxycarbonyl-1,4,7,10-tetrazacyclododecane-1,7-diacetic acid di-t-butyl ester

: 808112-81-4
4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester

Guidance literature:: In water; at 60 - 80 ℃; for 44h;

Reference yield:

: 120041-13-6
1-formaldehyde-1,4,7,10-tetraazadododecane

: 808112-81-4
4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium hydroxide / water; 1,4-dioxane / 4.5 h / pH 3

2.1: sodium hydroxide / water / 0.33 h

2.2: 22.5 h / 20 °C

3.1: hydroxylamine hydrochloride / ethanol / 48 h / Reflux

4.1: 36 h / 70 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydroxide; In 1,4-dioxane; ethanol; water; 4.1: |Kabachnik-Fields Reaction;
DOI:10.1055/s-0040-1707893

Reference yield:

: 857677-14-6
C₂₉H₄₆N₄O₇

: 808112-81-4
4-(phenylmethoxy)carbonyl-10-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid bis(1,1-dimethylethyl)ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / ethanol / 48 h / Reflux

2: 36 h / 70 °C

With hydroxylamine hydrochloride; In ethanol; 2: |Kabachnik-Fields Reaction;
DOI:10.1055/s-0040-1707893