3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

Base Information

Chemical Name:3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate
CAS No.:1376514-37-2
Molecular Formula:C₁₅H₂₄O₃S*C₂₃H₃₅N₅O₃
Molecular Weight:713.982
Hs Code.:

3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

Synonyms:3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

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Chemical Property of 3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

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Technology Process of 3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

There total 8 articles about 3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-35-0
2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

: 22724-81-8,16369-14-5
L-norvalinol

: 1376514-37-2
3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: With trifluoroacetic acid; In propyl cyanide; at 120 ℃; for 30h;

Reference yield:

: 854778-42-0
4-bromo-1-(bromomethyl)-2-methoxybenzene

: 1376514-37-2
3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 70 °C

2.1: methanol / 16 h / 65 °C

3.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

4.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 24 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 2250.23 Torr

6.1: trifluoroacetic acid / propyl cyanide / 30 h / 120 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; propyl cyanide; ethanol; ethyl acetate; mineral oil;

Reference yield:

: 17102-63-5
(4-bromo-2-methoxyphenyl)methanol

: 1376514-37-2
3-{4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxyphenyl}-N,N-dimethylpropanamide 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus tribromide / dichloromethane / 0.67 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 16 h / 70 °C

3.1: methanol / 16 h / 65 °C

4.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

5.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 24 h / Reflux

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 2250.23 Torr

7.1: trifluoroacetic acid / propyl cyanide / 30 h / 120 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; phosphorus tribromide; sodium hydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; propyl cyanide; ethanol; dichloromethane; ethyl acetate; mineral oil;