(2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine

Base Information

• Chemical Name: (2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine
• CAS No.: 98380-61-1
• Molecular Formula: C₃₇H₄₂N₂O₂
• Molecular Weight: 546.753

Synonyms:(2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine

Chemical Property of (2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine

There total 3 articles about (2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-(3S,4R)-3-<(3'R,4'S)-2'-oxo-3'-phenoxy-4'-phenylazetidin-1'-yl>-4-phenylazetidin-2-one (98380-56-4) → (2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine (98380-61-1)

Guidance literature:

With chlorohydroalane; In diethyl ether; for 1.5h; Heating;

DOI:10.1016/S0040-4039(00)94772-5

Reference yield:

(3S,4R)-1-((S)-1-Benzyloxymethyl-3-methyl-butyl)-4-phenyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-azetidin-2-one (98380-66-6,107079-80-1,107079-81-2) → (2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine (98380-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 deg C -> RT, overnight

2: 86 percent / AlH₂Cl / diethyl ether / Heating

With chlorohydroalane; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jo00018a012

Reference yield:

Phenoxyacetyl chloride (701-99-5) → (2R,3R)-1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-2-phenyl-3-<(2'S,3'S)-2'-phenyl-3'-phenoxyazetidinyl>azetidine (98380-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 deg C -> RT, overnight

2: 86 percent / AlH₂Cl / diethyl ether / Heating

With chlorohydroalane; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jo00018a012

upstream raw materials:

1-<(S)-1-<(benzyloxy)methyl>-3-methylbutyl>-(3S,4R)-3-<(3'R,4'S)-2'-oxo-3'-phenoxy-4'-phenylazetidin-1'-yl>-4-phenylazetidin-2-one

(3S,4R)-1-((S)-1-Benzyloxymethyl-3-methyl-butyl)-4-phenyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-azetidin-2-one

Phenoxyacetyl chloride

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