1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea

Base Information

Chemical Name:1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea
CAS No.:1380281-41-3
Molecular Formula:C₂₆H₂₃F₂N₅O₂
Molecular Weight:475.498
Hs Code.:

Synonyms:1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea

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Chemical Property of 1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea

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Technology Process of 1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea

There total 12 articles about 1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 75-44-5
phosgene

: 1380281-63-9
2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

: 1380281-41-3
1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea

Guidance literature:: phosgene; 2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol; In toluene; for 2h;

With ammonia; In methanol; toluene; for 2h;

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1380281-63-9
2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol

: 1380281-41-3
1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea

Guidance literature:: bis(trichloromethyl) carbonate; 2-(4-{3-[6-(2,4-Difluoro-phenyl)-pyridin-2-ylamino]-4-methylphenyl}-pyrimidin-2-yl)-propan-2-ol; In toluene; at 85 ℃; for 18h;

With ammonium hydroxide; In toluene; Cooling;

Reference yield:

: 1380281-57-1
2-bromo-6-(2,4-difluorophenyl)pyridine

: 1380281-41-3
1-(6-(2,4-difluorophenyl)pyridin-2-yl)-1-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

2.1: toluene / 18 h / 85 °C

2.2: Cooling

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene;