(1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate

Base Information

Chemical Name:(1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate
CAS No.:1268671-96-0
Molecular Formula:C₂₅H₃₄N₂O₃
Molecular Weight:410.557
Hs Code.:

Synonyms:(1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate

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Chemical Property of (1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate

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Technology Process of (1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate

There total 2 articles about (1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 123-75-1
pyrrolidine

: 1268671-82-4
C₂₁H₂₇NO₄

: 1268671-96-0
(1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate

Guidance literature:: With tert-butyl alcohol; In benzene; for 10h; Reflux;
DOI:10.1016/j.tet.2010.12.009

Reference yield:

: 72324-46-0
6-ethyl-2,2-dimethyl-2H,4H-1,3-dioxin-4-one

: 1268671-96-0
(1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux

2: tert-butyl alcohol / benzene / 10 h / Reflux

With tert-butyl alcohol; In 5,5-dimethyl-1,3-cyclohexadiene; benzene;
DOI:10.1016/j.tet.2010.12.009

Reference yield:

: 1268671-96-0
(1S,2R,4R)-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acid phenylamid-2-yl (E)-3-(pyrrolidin-1-yl)pent-2-enoate

: 616207-71-7,518348-13-5
(3S,4R,5S)-prelactone B

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 2 h / -78 - 20 °C

2.1: hydrogenchloride; water / tetrahydrofuran / 22 h / 20 °C

3.1: 5% Pd(II)/C(eggshell); hydrogen / ethanol / 20 h / 760.05 Torr

With hydrogenchloride; 5% Pd(II)/C(eggshell); water; hydrogen; lithium diisopropyl amide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2010.12.009