(S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester

Base Information

Chemical Name:(S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester
CAS No.:1256386-24-9
Molecular Formula:C₂₄H₃₂BrN₅O₅
Molecular Weight:550.453
Hs Code.:

Synonyms:(S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester

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Chemical Property of (S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester

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Technology Process of (S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester

There total 4 articles about (S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256386-95-4
(S,S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-3-(2-methoxycarbonylamino-3-methylbutyryl)imidazolidine-1-carboxlic acid tert-butyl ester

: 1256386-24-9
(S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester

Guidance literature:: With ammonium acetate; In m-xylene; at 135 ℃; for 0.75h;

Reference yield:

: 1256386-93-2
(S,S)-1-benzyl-3-(2-methoxycarbonylamino-3-methylbutyryl)imidazolidine-4-carboxlic acid methyl ester

: 1256386-24-9
(S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

1.2: 1 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 1.5 h / 20 °C

4.1: ammonium acetate / m-xylene / 0.75 h / 135 °C

With ammonium acetate; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; m-xylene;

Reference yield:

: (S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)imidazolidine-1,4-dicarboxlic acid 1-tert-butyl ester

: 1256386-24-9
(S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: ammonium acetate / m-xylene / 0.75 h / 135 °C

With ammonium acetate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; m-xylene;