(S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester

Base Information

Chemical Name:(S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester
CAS No.:1256386-99-8
Molecular Formula:C₂₆H₂₈BrN₅O₄
Molecular Weight:554.443
Hs Code.:

Synonyms:(S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester

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Chemical Property of (S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester

Chemical Property:

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Technology Process of (S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester

There total 5 articles about (S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256386-24-9
(S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester

: 98-88-4
benzoyl chloride

: 1256386-99-8
(S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: (S,S)-4-(4-bromophenyl)-3'-(2-methoxycarbonylamino-3-methylbutyryl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxlic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 0.333333h;

benzoyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

Reference yield:

: 1256386-93-2
(S,S)-1-benzyl-3-(2-methoxycarbonylamino-3-methylbutyryl)imidazolidine-4-carboxlic acid methyl ester

: 1256386-99-8
(S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

1.2: 1 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 1.5 h / 20 °C

4.1: ammonium acetate / m-xylene / 0.75 h / 135 °C

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C

5.2: 0.17 h / 20 °C

With hydrogenchloride; ammonium acetate; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; m-xylene;

Reference yield:

: (S,S)-3-(2-methoxycarbonylamino-3-methylbutyryl)imidazolidine-1,4-dicarboxlic acid 1-tert-butyl ester

: 1256386-99-8
(S,S)-(1-(1'-benzoyl-4-(4-bromophenyl)-1',2',4',5'-tetrahydro-1H-[2,4']biimidazol-3'-carbonyl)-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: ammonium acetate / m-xylene / 0.75 h / 135 °C

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.33 h / 20 °C

3.2: 0.17 h / 20 °C

With hydrogenchloride; ammonium acetate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; m-xylene;