tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate

Base Information

Chemical Name:tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate
CAS No.:1233361-26-6
Molecular Formula:C₂₆H₂₉N₇O₄
Molecular Weight:503.561
Hs Code.:

Synonyms:tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate

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Chemical Property of tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate

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Technology Process of tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate

There total 8 articles about tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1100598-44-4
2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 1233361-26-6
tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate

Guidance literature:: 2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one; 2-(N-tert-butoxycarbonylamino)ethanol; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With di-tert-butyl-diazodicarboxylate; In N,N-dimethyl-formamide; at 20 ℃; for 21h;

Reference yield:

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1233361-26-6
tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate tribasic trihydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

2.1: thionyl chloride / dichloromethane / 3 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: potassium acetate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Inert atmosphere

4.2: 18 h / 70 °C / Inert atmosphere

5.1: water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

5.2: pH 1

6.1: polymer-bound triphenylphosphine / N,N-dimethyl-formamide / 0.25 h / 20 °C

6.2: 21 h / 20 °C

With thionyl chloride; potassium phosphate tribasic trihydrate; water; potassium acetate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1100598-42-2
2-[3-(5-bromo-pyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

: 1233361-26-6
tert-butyl [2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)ethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Inert atmosphere

1.2: 18 h / 70 °C / Inert atmosphere

2.1: water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2.2: pH 1

3.1: polymer-bound triphenylphosphine / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 21 h / 20 °C

With water; potassium acetate; In tetrahydrofuran; N,N-dimethyl-formamide;