methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate

Base Information

Chemical Name:methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate
CAS No.:1173283-49-2
Molecular Formula:C₄₅H₄₄N₂O₆S
Molecular Weight:740.92
Hs Code.:

Synonyms:methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate

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Chemical Property of methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate

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Technology Process of methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate

There total 5 articles about methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1173283-48-1
(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxylic acid

: 58885-35-1,115545-85-2
S-trityl-L-cysteine methyl ether

: 1173283-49-2
methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

Reference yield: 82.0%

: 1173283-48-1
(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxylic acid

: 62675-68-7
S-(triphenylmethyl)-L-cysteine methyl ester hydrochloride

: 1173283-49-2
methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 4 - 20 ℃;
DOI:10.1002/chem.201000963

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1173283-49-2
methyl (R)-2-[(3R,5R)-2-[(9H-fluoren-9-yl)methoxycarbonyl]-3-isopropylisoxazolidine-5-carboxamido]-3-(triphenylmethylthio)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water;