N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide

Base Information

Chemical Name:N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide
CAS No.:1264835-55-3
Molecular Formula:C₃₄H₃₅N₃O₅S
Molecular Weight:597.735
Hs Code.:

Synonyms:N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide

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Chemical Property of N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide

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Technology Process of N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide

There total 6 articles about N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1264836-21-6
4-(((3-amino-2-methylphenyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)methyl)benzonitrile

: 124-63-0
methanesulfonyl chloride

: 1264835-55-3
N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide

Guidance literature:: With pyridine; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: N-{4-[3-(allyloxy)phenoxy]benzyl}-N-(2-methyl-3-nitrophenyl)amine

: 1264835-55-3
N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 40 h / 90 - 100 °C / Inert atmosphere

2: potassium carbonate; methanol / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 3 h / 50 - 60 °C / Inert atmosphere

3: caesium carbonate / tetrabutylammomium bromide / N,N-dimethyl-formamide / 2 h / 100 - 110 °C

4: ammonium chloride; iron / ethanol; water / 2 h / Reflux

5: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; methanol; iron; potassium carbonate; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1264836-10-3
4-(((4-(3-hydroxyphenoxy)benzyl)(2-methyl-3-nitrophenyl)amino)methyl)benzonitrile

: 1264835-55-3
N-(3-((4-cyanobenzyl)(4-(3-((tetrahydrofuran-3-yl)methoxy)phenoxy)benzyl)amino)-2-methylphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tetrabutylammomium bromide / N,N-dimethyl-formamide / 2 h / 100 - 110 °C

2: ammonium chloride; iron / ethanol; water / 2 h / Reflux

3: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; iron; ammonium chloride; caesium carbonate; tetrabutylammomium bromide; In ethanol; water; N,N-dimethyl-formamide;