di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate

Base Information

Chemical Name:di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate
CAS No.:239100-60-8
Molecular Formula:C₂₄H₄₀O₆Si
Molecular Weight:452.663
Hs Code.:

Synonyms:di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate

Chemical Property:

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Technology Process of di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate

There total 3 articles about di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-77-4
chloro-trimethyl-silane

: 239100-59-5
di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-hydroxypropyl>malonate

: 239100-60-8
di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; 0 deg C to rt;
DOI:10.1016/S0040-4020(99)00367-1

Reference yield:

: 541-16-2
t-butyl malonate

: 239100-60-8
di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate

Guidance literature:: Multi-step reaction with 2 steps

1: 26.2 mg / 1.) ZnCl₂, 2.) LHMDS / tetrahydrofuran / 1.) rt, 1.5 h, 2.) -98 deg C, 20 min

2: 91 percent / imidazole / dimethylformamide / 0 deg C to rt

With 1H-imidazole; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(99)00367-1

Reference yield:

: 53346-05-7,41954-96-5,81445-44-5,81445-45-6
(R)-2-benzyloxypropanal

: 239100-60-8
di-tert-butyl 2-<(1S,2R)-2-benzyloxy-1-<(trimethylsilyl)oxy>propyl>malonate

Guidance literature:: Multi-step reaction with 2 steps

1: 26.2 mg / 1.) ZnCl₂, 2.) LHMDS / tetrahydrofuran / 1.) rt, 1.5 h, 2.) -98 deg C, 20 min

2: 91 percent / imidazole / dimethylformamide / 0 deg C to rt

With 1H-imidazole; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(99)00367-1