methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate

Base Information

Chemical Name:methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate
CAS No.:1186080-86-3
Molecular Formula:C₂HF₃O₂*C₂₇H₃₇N₅O₃
Molecular Weight:593.646
Hs Code.:

Synonyms:methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate

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Chemical Property of methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate

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Technology Process of methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate

There total 4 articles about methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 850567-96-3
(4-((methoxycarbonyl) amino)phenyl)boronic acid

: 1186081-66-2
N-[(5-chloropyrazin-2-yl)methyl]-N-cyclopropyl-1-(2-ethylbutanoyl)piperidine4-amine

: 76-05-1
trifluoroacetic acid

: 1186080-86-3
methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate

Guidance literature:: (4-((methoxycarbonyl) amino)phenyl)boronic acid; N-[(5-chloropyrazin-2-yl)methyl]-N-cyclopropyl-1-(2-ethylbutanoyl)piperidine4-amine; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 - 85 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 105985-21-5
2-chloro-5-pyrazinylmethyl chloride

: 1186080-86-3
methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 70 °C

2: sodium cyanoborohydride; acetic acid / methanol / 62 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 - 85 °C

With sodium cyanoborohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water; acetonitrile; 3: Suzuki Coupling;

Reference yield:

: 1016511-94-6
1-(4-aminopiperidin-1-yl)-2-ethylbutan-1-one

: 1186080-86-3
methyl {4-[5-({cyclopropyl[1-(2-ethylbutanoyl)piperidin-4-yl]amino}methyl)pyrazin-2-yl]phenyl}carbamate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 70 °C

2: sodium cyanoborohydride; acetic acid / methanol / 62 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 - 85 °C

With sodium cyanoborohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water; acetonitrile; 3: Suzuki Coupling;