(2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

Base Information

Chemical Name:(2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid
CAS No.:1030836-40-8
Molecular Formula:C₂₇H₃₉NO₅Si
Molecular Weight:485.696
Hs Code.:

Synonyms:(2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

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Chemical Property of (2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

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Technology Process of (2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

There total 1 articles about (2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1030836-28-2
methyl (2S,4S)-2-(tert-butoxycarbonyl)amino-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoate

: 1030836-40-8
(2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

Guidance literature:: methyl (2S,4S)-2-(tert-butoxycarbonyl)amino-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoate; With lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h;

With hydrogenchloride; In water; ethyl acetate;
DOI:10.1021/ol800551g

Reference yield: 70.0%

: 2033-24-1
cycl-isopropylidene malonate

: 1030836-40-8
(2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

: 1214247-58-1
C₂₉H₃₉NO₅Si

Guidance literature:: cycl-isopropylidene malonate; (2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid; With dmap; In dichloromethane; at 0 ℃; Inert atmosphere;

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

In ethyl acetate; for 0.5h; Inert atmosphere; Reflux;
DOI:10.1021/ol100095p

Reference yield: 69.0%

: 1030836-40-8
(2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

: 74-88-4
methyl iodide

: 1030836-29-3
(2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

Guidance literature:: (2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid; methyl iodide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 16h;

With citric acid; In tetrahydrofuran; water;
DOI:10.1021/ol800551g