(2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

Base Information

Chemical Name:(2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid
CAS No.:1030836-29-3
Molecular Formula:C₂₈H₄₁NO₅Si
Molecular Weight:499.723
Hs Code.:

Synonyms:(2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

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Technology Process of (2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

There total 1 articles about (2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1030836-40-8
(2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

: 74-88-4
methyl iodide

: 1030836-29-3
(2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

Guidance literature:: (2S,4S)-2-(tert-butoxycarbonylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid; methyl iodide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 16h;

With citric acid; In tetrahydrofuran; water;
DOI:10.1021/ol800551g

Reference yield: 87.0%

: 1030836-29-3
(2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoic acid

: 1030836-30-6
(2S,4S)-2-(N-tert-butoxycarbonyl-N-methylamino)-5-(tert-butyldiphenylsilyloxy)-4-methylpentanoamide

Guidance literature:: With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1021/ol800551g