1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene

Base Information

Chemical Name:1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene
CAS No.:1026743-80-5
Molecular Formula:C₂₁H₂₁F₃O₄S
Molecular Weight:426.457
Hs Code.:

Synonyms:1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene

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Technology Process of 1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene

There total 10 articles about 1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025916-25-9
1-[2-(4-trifluoromethylphenyl)-4,4-dicarbomethoxycyclopenten-1-yl]-4-(methylsulfonyl)benzene

: 1026743-80-5
1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1021/jm950664x

Reference yield:

: 50413-24-6
2-bromo-1-(4-methanesulfonylphenyl)ethanone

: 1026743-80-5
1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1: 63.3 percent / K₂CO₃, KI / tetrahydrofuran / 6 h / Ambient temperature

2: K₂CO₃, KI / tetrahydrofuran

3: TiCl₃, zinc dust / 1,2-dimethoxy-ethane / 1 h / Heating

4: DIBAL / tetrahydrofuran / 0.25 h / -78 °C

With titanium(III) chloride; diisobutylaluminium hydride; potassium carbonate; potassium iodide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1021/jm950664x

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 1026743-80-5
1-[2-(4-trifluoromethylphenyl)-4,4-di(hydroxymethyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / mCPBA / CH₂Cl₂ / Ambient temperature

2: 15.7 g / HCl, bromine / acetic acid

3: 63.3 percent / K₂CO₃, KI / tetrahydrofuran / 6 h / Ambient temperature

4: K₂CO₃, KI / tetrahydrofuran

5: TiCl₃, zinc dust / 1,2-dimethoxy-ethane / 1 h / Heating

6: DIBAL / tetrahydrofuran / 0.25 h / -78 °C

With hydrogenchloride; titanium(III) chloride; bromine; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; acetic acid;
DOI:10.1021/jm950664x