5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:154891-05-1
Molecular Formula:C₂₅H₂₃ClN₂O₂
Molecular Weight:418.923
Hs Code.:

Synonyms:5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

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Chemical Property of 5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

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Technology Process of 5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 1 articles about 5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 150681-19-9
5-hydroxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

: 154891-05-1
5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(00)00388-4

Reference yield:

: 154891-05-1
5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

: acetic acid 5-hydroxy-1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 38.0 g / sodium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3.5 h / Heating

2: 75 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 h / 0 °C

3: 72 percent / potassium hydroxide / dimethylsulfoxide; H₂O / 7 h / 100 °C

4: lipase QL / diisopropyl ether; dimethylformamide / 22 h / 40 °C

With potassium hydroxide; Lipase QL; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Dehydrochlorination / 2: Epoxidation / 3: Ring cleavage / 4: Acetylation;
DOI:10.1016/S0040-4020(00)00388-4

Reference yield:

: 154891-05-1
5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

: acetic acid 4-acetoxy-1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 38.0 g / sodium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3.5 h / Heating

2: 75 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 h / 0 °C

3: 72 percent / potassium hydroxide / dimethylsulfoxide; H₂O / 7 h / 100 °C

4: lipase QL / diisopropyl ether; dimethylformamide / 22 h / 40 °C

With potassium hydroxide; Lipase QL; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Dehydrochlorination / 2: Epoxidation / 3: Ring cleavage / 4: Acetylation;
DOI:10.1016/S0040-4020(00)00388-4