4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:176970-20-0
Molecular Formula:C₂₅H₂₂N₂O₃
Molecular Weight:398.461
Hs Code.:

Synonyms:4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

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Chemical Property of 4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

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Technology Process of 4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 3 articles about 4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 176970-19-7
1-[4-(2-methylbenzoylamino)benzoyl]-2,3-dihydro-1H-1-benzazepine

: 176970-20-0
4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 20h;
DOI:10.1016/S0040-4020(00)00388-4

Reference yield:

: 150681-19-9
5-hydroxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

: 176970-20-0
4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / thionyl chloride / CH₂Cl₂; dimethylformamide / 2 h / 20 °C

2: 38.0 g / sodium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3.5 h / Heating

3: 75 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 h / 0 °C

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Chlorination / 2: Dehydrochlorination / 3: Epoxidation;
DOI:10.1016/S0040-4020(00)00388-4

Reference yield:

: 154891-05-1
5-chloro-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

: 176970-20-0
4,5-epoxy-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 38.0 g / sodium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3.5 h / Heating

2: 75 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In dichloromethane; acetonitrile; 1: Dehydrochlorination / 2: Epoxidation;
DOI:10.1016/S0040-4020(00)00388-4