1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline

Base Information

Chemical Name:1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline
CAS No.:1320362-75-1
Molecular Formula:C₂₈H₂₁NO₃
Molecular Weight:419.48
Hs Code.:

Synonyms:1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline

Suppliers and Price of 1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline

There total 4 articles about 1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1235868-29-7
4-iodo-1-methoxy-3-phenyl-1H-pyrano[4,3-b]quinoline

: 768-60-5
4-methoxyphenylacetylen

: 1320362-75-1
1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline

Guidance literature:: With trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In acetonitrile; at 70 ℃; for 4h; Inert atmosphere;
DOI:10.1021/co200100z

Reference yield:

: 868765-12-2
2-phenylethynyl-quinoline-3-carbaldehyde

: 1320362-75-1
1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; potassium carbonate / dichloromethane / 2 h / 20 °C

2: trans-bis(triphenylphosphine)palladium dichloride; triethylamine / acetonitrile / 4 h / 70 °C / Inert atmosphere

With trans-bis(triphenylphosphine)palladium dichloride; iodine; potassium carbonate; triethylamine; In dichloromethane; acetonitrile; 2: Sonogashira coupling;
DOI:10.1021/co200100z

Reference yield:

: 73568-25-9
2-chloro-3-quinoline carboxaldehyde

: 1320362-75-1
1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 60 °C

2: iodine; potassium carbonate / dichloromethane / 2 h / 20 °C

3: trans-bis(triphenylphosphine)palladium dichloride; triethylamine / acetonitrile / 4 h / 70 °C / Inert atmosphere

With trans-bis(triphenylphosphine)palladium dichloride; iodine; potassium carbonate; triethylamine; In dichloromethane; acetonitrile; 1: Sonogashira coupling / 3: Sonogashira coupling;
DOI:10.1021/co200100z