(4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane

Base Information

Chemical Name:(4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane
CAS No.:196600-41-6
Molecular Formula:C₂₈H₄₆O₅Si
Molecular Weight:490.756
Hs Code.:

Synonyms:(4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane

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Chemical Property of (4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane

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Technology Process of (4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane

There total 9 articles about (4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 116-11-0
2-Methoxypropene

: 196600-31-4
(2S,3S)-1-[(2,3-dimethyl-2-butyl)dimthylsilyloxy]-5-(2,5-dimethoxy-3,4,6-trimethylphenyl)-3-methylpent-4-yne-2,3-diol

: 196600-41-6
(4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1055/s-1997-1278

Reference yield:

: 4537-09-1
1,4-dimethoxy-2,3,5-trimethyl-benzene

: 196600-41-6
(4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / I₂, H₅IO₆, HOAc, H₂SO₄ / H₂O / 17 h / 45 °C

2: 1.) DMPU, n-BuLi, 2.) ZnCl₂, 3.) Pd(PPh₃)4

3: AD-mix-α / 2-methyl-propan-2-ol; H2O / 72 h / 0 °C

4: 87 percent / PPTS / CH₂Cl₂ / 4 h / Ambient temperature

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; AD-mix-α; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; iodine; pyridinium p-toluenesulfonate; acetic acid; periodic acid; zinc(II) chloride; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1055/s-1997-1278

Reference yield:

: 131426-03-4
1-iodo-2,5-bis(methoxy)-3,4,6-trimethylbenzene

: 196600-41-6
(4S,5S)-5-[(2,3-dimethyl-2-butyl)dimethylsilyloxymethyl]-2,2,4-trimethyl-4-(2,5-dimethoxy-3,4,6-trimethylphenylethynyl)-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DMPU, n-BuLi, 2.) ZnCl₂, 3.) Pd(PPh₃)4

2: AD-mix-α / 2-methyl-propan-2-ol; H2O / 72 h / 0 °C

3: 87 percent / PPTS / CH₂Cl₂ / 4 h / Ambient temperature

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; AD-mix-α; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; pyridinium p-toluenesulfonate; zinc(II) chloride; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1055/s-1997-1278