tert-butoxycarbonyl-α-trimethylstannylbenzylamine

Base Information

• Chemical Name: tert-butoxycarbonyl-α-trimethylstannylbenzylamine
• CAS No.: 174311-00-3
• Molecular Formula: C₁₅H₂₅NO₂Sn
• Molecular Weight: 370.079
• Mol file: 174311-00-3.mol

Synonyms:tert-butoxycarbonyl-α-trimethylstannylbenzylamine

Chemical Property of tert-butoxycarbonyl-α-trimethylstannylbenzylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butoxycarbonyl-α-trimethylstannylbenzylamine

There total 1 articles about tert-butoxycarbonyl-α-trimethylstannylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-tert-butoxycarbonylbenzylamine (42116-44-9) + trimethyltin(IV)chloride (1066-45-1) → tert-butoxycarbonyl-α-trimethylstannylbenzylamine (174311-00-3)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; hexane; (inert atm.); stirring(-78°C, 30 + 10 min), quenching (aq. H3PO4); extn. (Et2O), washing, drying (MgSO4), chromy. (SiO2, hexane, ethyl acetate);

DOI:10.1021/ja9524661

Reference yield: 12.0%

tert-butoxycarbonyl-α-trimethylstannylbenzylamine (174311-00-3) + 1.3-chlorobromopropane (109-70-6) → tert-butoxy-N-(3-chloropropyl)-α-(trimethylstannyl)benzylamine (174310-88-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; (inert atm.); stirring (room temp., 7 h), quenching (aq. NH4Cl); extn. (Et2O), chromy. (silica, hexane/ethyl acetate);

DOI:10.1021/ja9524661

upstream raw materials:

N-tert-butoxycarbonylbenzylamine

trimethyltin(IV)chloride

Downstream raw materials:

tert-butoxy-N-(3-chloropropyl)-α-(trimethylstannyl)benzylamine