(3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one

Base Information

Chemical Name:(3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one
CAS No.:287117-58-2
Molecular Formula:C₂₂H₃₅NO₃Si
Molecular Weight:389.61
Hs Code.:

Synonyms:(3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one

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Chemical Property of (3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one

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Technology Process of (3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one

There total 6 articles about (3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 13154-24-0
triisopropylsilyl chloride

: (3R,4S)-3-hydroxy-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-azetidin-2-one

: 287117-58-2
(3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/acs.joc.8b02333

Reference yield:

: 104-94-9
4-methoxy-aniline

: 287117-58-2
(3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂SO₄ / CH₂Cl₂ / 1 h

2: 1.) LDA / 1.) THF, hexane, -84 deg C, 2 h, 2.) THF, hexane, a) -84 deg C, 2 h, b) from -84 deg C to RT, overnight

With sodium sulfate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm960563e

Reference yield:

: 132127-27-6
(1R,2S)-2-phenyl-1-cyclohexyl<(triisopropylsilyl)oxy>acetate

: 186347-74-0,255826-65-4
N-(4-methoxyphenyl)-(E)-2-butenaldimine

: 287117-58-2
(3R,4S)-1-(4-methoxyphenyl)-4-((E)-prop-1-en-1-yl)-3-((triisopropylsilyl)oxy)azetidin-2-one

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -84 deg C, 2 h, 2.) THF, hexane, a) -84 deg C, 2 h, b) from -84 deg C to RT, overnight;
DOI:10.1021/jm960563e