(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

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Chemical Name:(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid
CAS No.:331819-86-4
Molecular Formula:C₂₀H₃₂N₂O₆
Molecular Weight:396.484
Hs Code.:

Synonyms:(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

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Chemical Property of (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

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Technology Process of (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

There total 16 articles about (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 331819-84-2
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

: 331819-86-4
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1039/b008970m

Reference yield:

: 37439-79-5
2-allyl-3-acetamidophenol

: 331819-86-4
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 14 steps

1.1: 82 percent / K₂CO₃ / acetone / Heating

2.1: 81 percent / HCl / 2 h / Heating

3.1: 72 percent / toluene / 24 h / Heating

4.1: 74 percent / OsO₄; NMO / acetone / 20 °C

5.1: 69 percent / aq. NaIO₄ / 2-methyl-propan-2-ol / 20 °C

6.1: CHCl₃

7.1: CHCl₃ / 10 h / 0 - 20 °C

8.1: 81 percent / HCl / diethyl ether / 48 h / 0 - 20 °C

9.1: Pb(OAc)4 / CH₂Cl₂; methanol / 0.25 h

9.2: H₂ / 20percent Pd(OH)2/C / ethanol / 2585.81 Torr

10.1: Et₃N / tetrahydrofuran / 20 °C

11.1: 96 percent / LiBH₄ / tetrahydrofuran / 8 h / 0 - 20 °C

12.1: 96 percent / NH₂OH*HCl; Et₃N / propan-2-ol; H₂O / 24 h / Heating

13.1: 87 percent / 2,6-lutidine / 1,2-dichloro-ethane

14.1: 100 percent / H₂ / Pd/C / ethanol

With 2,6-dimethylpyridine; lead(IV) acetate; hydrogenchloride; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; water; 1,2-dichloro-ethane; isopropyl alcohol; acetone; toluene; tert-butyl alcohol;
DOI:10.1039/b008970m

Reference yield:

: 37439-78-4
N-(3-(allyloxy)phenyl)acetamide

: 331819-86-4
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 15 steps

1.1: PhNMe₂ / 6 h / Heating

2.1: 82 percent / K₂CO₃ / acetone / Heating

3.1: 81 percent / HCl / 2 h / Heating

4.1: 72 percent / toluene / 24 h / Heating

5.1: 74 percent / OsO₄; NMO / acetone / 20 °C

6.1: 69 percent / aq. NaIO₄ / 2-methyl-propan-2-ol / 20 °C

7.1: CHCl₃

8.1: CHCl₃ / 10 h / 0 - 20 °C

9.1: 81 percent / HCl / diethyl ether / 48 h / 0 - 20 °C

10.1: Pb(OAc)4 / CH₂Cl₂; methanol / 0.25 h

10.2: H₂ / 20percent Pd(OH)2/C / ethanol / 2585.81 Torr

11.1: Et₃N / tetrahydrofuran / 20 °C

12.1: 96 percent / LiBH₄ / tetrahydrofuran / 8 h / 0 - 20 °C

13.1: 96 percent / NH₂OH*HCl; Et₃N / propan-2-ol; H₂O / 24 h / Heating

14.1: 87 percent / 2,6-lutidine / 1,2-dichloro-ethane

15.1: 100 percent / H₂ / Pd/C / ethanol

With 2,6-dimethylpyridine; lead(IV) acetate; hydrogenchloride; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; hydroxylamine hydrochloride; hydrogen; potassium carbonate; N,N-dimethyl-aniline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; water; 1,2-dichloro-ethane; isopropyl alcohol; acetone; toluene; tert-butyl alcohol; 1.1: Claisen rearrangement;
DOI:10.1039/b008970m