(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

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Chemical Name:(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester
CAS No.:331819-84-2
Molecular Formula:C₂₇H₃₈N₂O₆
Molecular Weight:486.609
Hs Code.:

Synonyms:(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

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Chemical Property of (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

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Technology Process of (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

There total 15 articles about (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 131423-64-8
benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate

: 331819-82-0
[2-(2-amino-6-methoxy-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

: 331819-84-2
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: With 2,6-dimethylpyridine; In 1,2-dichloro-ethane;
DOI:10.1039/b008970m

Reference yield:

: 37439-79-5
2-allyl-3-acetamidophenol

: 331819-84-2
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: 82 percent / K₂CO₃ / acetone / Heating

2.1: 81 percent / HCl / 2 h / Heating

3.1: 72 percent / toluene / 24 h / Heating

4.1: 74 percent / OsO₄; NMO / acetone / 20 °C

5.1: 69 percent / aq. NaIO₄ / 2-methyl-propan-2-ol / 20 °C

6.1: CHCl₃

7.1: CHCl₃ / 10 h / 0 - 20 °C

8.1: 81 percent / HCl / diethyl ether / 48 h / 0 - 20 °C

9.1: Pb(OAc)4 / CH₂Cl₂; methanol / 0.25 h

9.2: H₂ / 20percent Pd(OH)2/C / ethanol / 2585.81 Torr

10.1: Et₃N / tetrahydrofuran / 20 °C

11.1: 96 percent / LiBH₄ / tetrahydrofuran / 8 h / 0 - 20 °C

12.1: 96 percent / NH₂OH*HCl; Et₃N / propan-2-ol; H₂O / 24 h / Heating

13.1: 87 percent / 2,6-lutidine / 1,2-dichloro-ethane

With 2,6-dimethylpyridine; lead(IV) acetate; hydrogenchloride; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; hydroxylamine hydrochloride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; 1,2-dichloro-ethane; isopropyl alcohol; acetone; toluene; tert-butyl alcohol;
DOI:10.1039/b008970m

Reference yield:

: 37439-78-4
N-(3-(allyloxy)phenyl)acetamide

: 331819-84-2
(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 14 steps

1.1: PhNMe₂ / 6 h / Heating

2.1: 82 percent / K₂CO₃ / acetone / Heating

3.1: 81 percent / HCl / 2 h / Heating

4.1: 72 percent / toluene / 24 h / Heating

5.1: 74 percent / OsO₄; NMO / acetone / 20 °C

6.1: 69 percent / aq. NaIO₄ / 2-methyl-propan-2-ol / 20 °C

7.1: CHCl₃

8.1: CHCl₃ / 10 h / 0 - 20 °C

9.1: 81 percent / HCl / diethyl ether / 48 h / 0 - 20 °C

10.1: Pb(OAc)4 / CH₂Cl₂; methanol / 0.25 h

10.2: H₂ / 20percent Pd(OH)2/C / ethanol / 2585.81 Torr

11.1: Et₃N / tetrahydrofuran / 20 °C

12.1: 96 percent / LiBH₄ / tetrahydrofuran / 8 h / 0 - 20 °C

13.1: 96 percent / NH₂OH*HCl; Et₃N / propan-2-ol; H₂O / 24 h / Heating

14.1: 87 percent / 2,6-lutidine / 1,2-dichloro-ethane

With 2,6-dimethylpyridine; lead(IV) acetate; hydrogenchloride; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; hydroxylamine hydrochloride; potassium carbonate; N,N-dimethyl-aniline; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; 1,2-dichloro-ethane; isopropyl alcohol; acetone; toluene; tert-butyl alcohol; 1.1: Claisen rearrangement;
DOI:10.1039/b008970m