37439-78-4

Upstream product

• 106-95-6 allyl bromide 
• 621-42-1 meta-hydroxyacetanilide 

Downstream Products

• 37439-79-5 2-allyl-3-acetamidophenol 
• 28583-69-9 acetic acid-(4-allyl-3-hydroxy-anilide) 
• 37439-80-8 1-acetoxy-3-acetylamino-2-allyl-benzene 
• 37439-82-0 2-acetoxy-4-acetylamino-1-allyl-benzene 
• 340774-75-6 2-allyl-3-methoxyaniline 
• 340774-74-5 acetic acid-(2-allyl-3-methoxy-anilide) 
• 340774-78-9 [2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-acetaldehyde 
• 340774-76-7 1-(2-allyl-3-methoxy-phenyl)-2,5-dimethyl-1H-pyrrole 
• 340774-77-8 3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propane-1,2-diol 
• 331819-82-0 [2-(2-amino-6-methoxy-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester 
• 340774-85-8 N-{2-[2-cyano-2-(2-hydroxy-1-phenyl-ethylamino)-ethyl]-3-methoxy-phenyl}-acetamide 
• 340774-82-5 2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester 
• 340774-84-7 {2-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester 
• 340774-79-0 (S)-3-[2-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-2-((R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile 

Relevant academic research and scientific papers

Silver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds.

Synthesis and anti-proliferative activity of substituted- anilinoquinazolines and its relation to EGFR inhibition

4-Anilinoquinazoline is a privileged scaffold in developing small molecule inhibitors of tyrosine kinases (TK) especially epidermal growth factor receptor (EGFR). 2 series belonging to 3'-substituted-4-anilinoquinazoline scaffold were synthesized and screened in vitro on isolated and a breast cancer cell line. The research aims at exploring the activity of compounds having diverse substituents at 3' position of the aniline moiety. Generally, the meta-substituted-anilinoquinazolines exhibited significant inhibitory activity against isolated enzyme as well as MCF-7 cancer cell line. For instance, compound 10b inhibited >99% of EGFR activities at 10 M concentration. 6 of the tested compounds exhibited range of anti-proliferative activity below 10 M potency. In particular, compounds 6e and 10b displayed the highest activity among the tested compounds with IC50 values equal to 8.6 and 4.84 M, respectively. Structure-based tools were utilized to rationalize EGFR-TK binding of compound 10b since it is the most active compound in the enzyme inhibition test. Georg Thieme Verlag KG Stuttgart.New York.

1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE

The present invention provides a compound represented by the formula (1) or a pharmacologically acceptable salt thereof, or a hydrate thereof (provided that a compound in which all of R4a, R4b, and R4c are hydrogen atoms is excluded.): [wherein R1 represents a hydrogen atom, R2 represents a hydrogen atom, R3 represents the formula: wherein R4a, R4b, and R4c are the same as or different from each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, etc.]

Synthesis of 7-methoxybenzolactam-V8 using a diastereoselective Strecker synthesis

7-Methoxybenzolactam-V8 (4) was synthesized using a diastereoselective Strecker reaction as the key step employing an ortho-substituted phenylacetaldehyde and (R)-phenylglycinol as the chiral auxiliary.