(E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

Base Information

Chemical Name:(E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide
CAS No.:1378942-65-4
Molecular Formula:C₁₉H₁₆N₂O₆
Molecular Weight:368.346
Hs Code.:

Synonyms:(E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

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Chemical Property of (E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

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Technology Process of (E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

There total 6 articles about (E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1378942-64-3
(E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate

: 1378942-65-4
(E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

Guidance literature:: With ethanolamine; In ethanol; at 20 ℃; for 0.5h;
DOI:10.1002/ddr.20442

Reference yield:

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: 1378942-65-4
(E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium nitrite; acetic acid / 0 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 12 h / 20 °C

3: titanium tetrachloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With dmap; titanium tetrachloride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bioorg.2019.103000