(E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate

Base Information

• Chemical Name: (E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate
• CAS No.: 1378942-64-3
• Molecular Formula: C₂₂H₂₀N₂O₈
• Molecular Weight: 440.409

Synonyms:(E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate

Chemical Property of (E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate

Chemical Property:

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Technology Process of (E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate

There total 2 articles about (E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-3-{4-[(ethoxycarbonyl)oxy]-3-methoxyphenyl}acrylic acid (42381-67-9,62621-20-9) + 3-(hydroxymethyl)-4-phenylfuroxan (135733-30-1) → (E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate (1378942-64-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1002/ddr.20442

Reference yield:

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) → (E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate (1378942-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 4 h / 20 - 50 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

With dmap; dicyclohexyl-carbodiimide; sodium hydroxide; In dichloromethane;

DOI:10.1002/ddr.20442

Reference yield: 89.0%

(E)-(4-phenyl-1,2,5-oxadiazol-3-yl)methyl 3-(4-(ethoxycarbonyloxy)-3-methoxyphenyl)acrylate (1378942-64-3) → (E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide (1378942-65-4)

Guidance literature:

With ethanolamine; In ethanol; at 20 ℃; for 0.5h;

DOI:10.1002/ddr.20442

upstream raw materials:

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

(2E)-3-{4-[(ethoxycarbonyl)oxy]-3-methoxyphenyl}acrylic acid

3-(hydroxymethyl)-4-phenylfuroxan

Downstream raw materials:

(E)-3-(((3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide

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