1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone

Base Information

Chemical Name:1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone
CAS No.:1138338-21-2
Molecular Formula:C₂₇H₃₅ClFNO₅
Molecular Weight:508.03
Hs Code.:

Synonyms:1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone

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Chemical Property of 1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone

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Technology Process of 1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone

There total 1 articles about 1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1138338-59-6
1-{2-(2-bromo-ethoxy)-5-chloro-3-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-6-methyl-phenyl}-ethanone

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1138338-21-2
1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone

Guidance literature:: t-butyl 4-hydroxy piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.1h;

1-{2-(2-bromo-ethoxy)-5-chloro-3-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-6-methyl-phenyl}-ethanone; With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield: 100.0%

: 1138338-21-2
1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone

: 1138338-22-3
1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-oxo-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone

Guidance literature:: 1-(3-chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-[2-(4-hvdroxy-piperidin-1-yl)-ethoxy]-4-methoxy-2-methyl-phenyl)-ethanone; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1.25h;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 1h;