2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester

Base Information

Chemical Name:2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester
CAS No.:869541-35-5
Molecular Formula:C₂₃H₁₉NO₇S
Molecular Weight:453.472
Hs Code.:

Synonyms:2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester

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Chemical Property of 2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester

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Technology Process of 2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester

There total 4 articles about 2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 869541-33-3
2-benzyl-1,3,3-trioxo-2,3-dihydro-1H-3λ⁶-naphtho[1,2-d]isothiazole-4-carboxylic acid

: 105-36-2
ethyl bromoacetate

: 869541-35-5
2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester

Guidance literature:: With potassium fluoride; In N,N-dimethyl-formamide; at 120 ℃;
DOI:10.1021/jm050382p

Reference yield:

: 869541-14-0
1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid

: 869541-35-5
2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaOEt / ethanol

1.2: 87 percent / dimethylformamide / 120 °C

2.1: 86 percent / aq. NaOH / dioxane / 20 °C

3.1: 70 percent / KF / dimethylformamide / 120 °C

With potassium fluoride; sodium hydroxide; sodium ethanolate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm050382p

Reference yield:

: 869541-13-9
2-tert-butylsulfamoylnaphthalene-1,3-dicarboxylic acid

: 869541-35-5
2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid ethoxycarbonylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / polyphosphoric acid / 0.25 h / 100 °C

2.1: NaOEt / ethanol

2.2: 87 percent / dimethylformamide / 120 °C

3.1: 86 percent / aq. NaOH / dioxane / 20 °C

4.1: 70 percent / KF / dimethylformamide / 120 °C

With potassium fluoride; sodium hydroxide; PPA; sodium ethanolate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm050382p