(2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-hydroxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate

Base Information

• Chemical Name: (2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-hydroxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate
• CAS No.: 1227732-55-9
• Molecular Formula: C₄₀H₇₀O₁₀Si₂
• Molecular Weight: 767.161
• Mol file: 1227732-55-9.mol

Synonyms:(2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-hydroxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate

Chemical Property of (2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-hydroxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-hydroxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate

There total 1 articles about (2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-hydroxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-4-hydroxy-8-(2-hydroxyethyl)-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate (1227732-54-8) + pivaloyl chloride (3282-30-2) → (2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-hydroxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate (1227732-55-9)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 5h;

DOI:10.1002/ejoc.200901285

Reference yield: 66.0%

trimethyl oxonium tetrafluoroborate + (2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-hydroxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate (1227732-55-9) → (2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-methoxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate (1227732-56-0)

Guidance literature:

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/ejoc.200901285

upstream raw materials:

(2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-4-hydroxy-8-(2-hydroxyethyl)-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate

pivaloyl chloride

Downstream raw materials:

(2R)-4-[(tert-butyl)(dimethyl)silyloxy]-1-{(2S,4S,6R,8S,10S)-10-[(tert-butyl)(dimethyl)silyloxy]-8-[2-(2,2-dimethylpropanoyloxy)ethyl]-4-methoxy-1,7-dioxaspiro[5.5]undec-2-yl}but-2-yl 4-methoxybenzoate