2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate
• CAS No.: 1256278-62-2
• Molecular Formula: C₁₅H₁₂F₂O₃S
• Molecular Weight: 310.321
• Mol file: 1256278-62-2.mol

Synonyms:2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate

Chemical Property of 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate

There total 13 articles about 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

iodobenzene (591-50-4) + 2,2-difluoro-1-tributylstannylethenyl p-toluenesulfonate (1256278-61-1) → 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate (1256278-62-2)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 10h; Inert atmosphere;

DOI:10.1021/ol1024037

Reference yield: 92.0%

2,2-difluoro-1-iodoethenyl p-toluenesulfonate + phenylboronic acid (98-80-6) → 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate (1256278-62-2)

Guidance literature:

With palladium diacetate; sodium carbonate; In methanol; at 20 ℃; for 15h; Reagent/catalyst; Inert atmosphere;

DOI:10.3762/bjoc.9.286

Reference yield: 80.0%

toluene-4-sulfonic acid 2,2,2-trifluoro-1-phenyl-ethyl ester (13652-13-6) → 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate (1256278-62-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.916667h; Inert atmosphere;

DOI:10.1021/ol102645g

upstream raw materials:

iodobenzene

2,2-difluoro-1-tributylstannylethenyl p-toluenesulfonate

2,2,2-Trifluoroacetophenone

1-phenyl-2,2,2-trifluoromethylethanol

Downstream raw materials:

1,1-difluoro-2,2-diphenylethylene

1-(2,2-difluoro-1-phenylvinyl)-4-methylbenzene

1-chloro-4-(2,2-difluoro-1-phenylvinyl)benzene

2-(2,2-difluoro-1-phenylvinyl)furan

Refernces

• 1、 Zhang, Rui,Ni, Chuanfa,Zhao, Yanchuan,Hu, Jinbo. "Synthesis of 2,2-diaryl-1,1-difluoroethenes via Pd-catalyzed dehydrosulfonylative cross-coupling of α-[difluoro(phenylsulfonyl)methyl]benzyl tosylates with arylboronic acids". . p. 5295 - 5302. Retrieved 2018/05/16.
• 2、 Lee, Hyo Young,Jeon, Jong Hee,Jeon, Sung Lan,Jeong, In Howa. "Preparation of 2,2-difluoro-1-arylethenylstannane as a precursor of 1,1-diaryl-2,2-difluoroethenes". body text. p. 379 - 380. Retrieved 2012/04/23.