1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE

Base Information

• Chemical Name: 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE
• CAS No.: 569-72-2
• Molecular Formula: C14H9F3
• Molecular Weight: 216.23
• Mol file: 569-72-2.mol

Synonyms:1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE

Chemical Property of 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 261.5°Cat760mmHg
• Flash Point: 97.6°C
• PSA: 0.00000
• Density: 1.199g/cm³
• LogP: 4.48160

Purity/Quality:

98%Min ^*data from raw suppliers

1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE

There total 56 articles about 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,1'-dichloro-2,2'-difluoroethene (79-35-6) + phenylboronic acid (98-80-6) → 1,1-difluoro-2,2-diphenylethylene (569-72-2)

Guidance literature:

With sodium tetrachloropalladate(II); cataCXium F sulf; potassium carbonate; In water; butan-1-ol; at 95 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b924772f

Reference yield: 93.0%

C5H9BrF2Si + diazodiphenylmethane (908093-98-1) → 1,1-difluoro-2,2-diphenylethylene (569-72-2)

Guidance literature:

With tetrabutylammomium bromide; In 1,2-dichloro-ethane; at 50 ℃; Temperature; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201509711

Reference yield: 89.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + diazodiphenylmethane (908093-98-1) → 1,1-difluoro-2,2-diphenylethylene (569-72-2)

Guidance literature:

With sodium iodide; In tetrahydrofuran; at 20 ℃; for 18h; Solvent; Temperature; Reagent/catalyst; Catalytic behavior; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.5b09888

upstream raw materials:

1-chloro-1,1-difluoro-2,2-diphenyl-ethane

benzophenone

sodium 2,2,2-trifluoroacetate

tributylphosphine

Downstream raw materials:

diphenamid

Refernces

• 1、 Li, Yuxiu,Li, Xiangqian,Li, Xiaowei,Shi, Dayong. "Visible-light-promotedE-selective synthesis of α-fluoro-β-arylalkenyl sulfidesviathe deoxygenation/isomerization process". supporting information. p. 2152 - 2155. Retrieved 2021/03/06.
• 2、 Wang, Qiang,Qu, Yi,Tian, Hao,Liu, Yuxiu,Song, Hongjian,Wang, Qingmin. "Trifluoromethylation and Monofluoroalkenylation of Alkenes through Radical–Radical Cross-Coupling". supporting information. p. 8686 - 8690. Retrieved 2019/06/17.