13652-13-6

Usage

Uses

Used in Pharmaceutical Industry:
2,2,2-Trifluoro-1-phenylethyl 4-methylbenzenesulfonate is used as a reagent or intermediate in organic synthesis for the production of various drugs and biologically active compounds. Its unique chemical structure allows for the creation of new pharmaceutical agents with potential therapeutic benefits.
Used in Agrochemicals:
In the agrochemical industry, 2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate serves as a key intermediate in the synthesis of various agrochemical products. Its incorporation into these products can enhance their effectiveness in agricultural applications.
Used in Organic Synthesis:
2,2,2-Trifluoro-1-phenylethyl 4-methylbenzenesulfonate is used as a building block for the synthesis of other complex organic molecules. Its versatile reactivity makes it a valuable component in the creation of a wide range of organic compounds for various applications.
Used in Chemical Reactions and Processes:
The chemical structure of 2,2,2-trifluoro-1-phenylethyl 4-methylbenzenesulfonate allows for its involvement in various chemical reactions and processes. Its unique properties enable it to act as a catalyst, reactant, or intermediate in the synthesis of new compounds and materials.

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 86669-62-7 α-Tosyloxy-α-(trifluoromethyl)phenylacetonitrile 
• 340-04-5 1-phenyl-2,2,2-trifluoromethylethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 434-42-4 1,1,1-trifluoro-2-bromo-2-phenylethane 
• 21249-93-4 (2,2,2-trifluoroethyl)benzene 
• 390-75-0 2-fluoro-1,1-diphenylethene 
• 1262431-40-2 1-(2-fluoro-1-phenylvinyl)-4-(trifluoromethyl)benzene 
• 1262431-38-8 (Z)-4-(2-fluoro-1-phenylvinyl)benzonitrile 
• 1262431-39-9 (E)-4-(2-fluoro-1-phenylvinyl)benzonitrile 
• 1262431-37-7 2-(2-fluoro-1-phenylvinyl)naphthalene 
• 1262431-43-5 2-(2-fluoro-1-phenylvinyl)naphthalene 
• 1262431-35-5 (E)-2-fluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 1262431-36-6 (Z)-2-fluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 1256278-62-2 2,2-difluoro-1-phenylvinyl 4-methylbenzenesulfonate 
• 657-84-1 sodium tosylate 

Relevant academic research and scientific papers

Synthesis of α-(trifluoromethyl)phenylacetonitrile. Anomalous reactions of α-tosyloxy-α-(trifluoromethyl)phenylacetonitrile with sodium borohydride

The hitherto unknown α-(trifluoromethyl)phenylacetonitrile has been synthesized by reduction of the cyanohydrin of α,α,α-trifluoroacetophenone.Sodium borohydride reduction of the corresponding cyanohydrin tosylate resulted in reductive decyanation in dimethyl sulphoxide and in reduction of the nitrile group in t-butanol. - Keywords: Synthesis; α-(Trifluoromethyl)phenylacetonitrile; Anomalous reactions; Sodium borohydride; NMR spectroscopy; IR spectroscopy, Mass spectrometry

Monofluorovinyl tosylate: A useful building block for the synthesis of terminal vinyl monofluorides via suzuki-Miyaura coupling

Monofluorovinyl tosylate was developed as a practical vinyl fluoride building block to couple with a variety of arylboronic acids in the presence of a palladium catalyst. The high stereoselectivity of 2-aryl-1-fluoroethene derivatives was achieved. This a

Profiling sulfonate ester stability: Identification of complementary protecting groups for sulfonates

(Figure presented) Sulfonation is prized for its ability to impart water-solubility to hydrophobic molecules such as dyes. This modification is usually performed as a final step, since sulfonated molecules are poorly soluble in most organic solvents, which complicates their synthesis and purification. This work compares the intrinsic lability of different sulfonate esters, identifying new sulfonate protecting groups and mild, selective cleavage conditions.

Solvolysis of 1-Aryl-2,2,2-trifluoroethyl Sulfonates. Kinetic and Stereochemical Effects in the Generation of Highly Electron-Deficient Carbocations

Solvolysis rates of sulfonates XC6H4CH(O3SR)CF3 (R = p-Tol or CF3) correlate with ?+(X) with values of ρ+ between -6.7 and -11.9 depending upon solvent.For the tosylates the rates depend on the solvent parameter YOTs with

Proton-Transfer Reactions. 2. Effects of Internal Return on Reactivity Difference between Alkoxide-Promoted Eliminations in tert-Butyl alcohol and Ethyl Alcohol

Kinetics of alkoxide-promoted dehydrofluorination reactions are reported for the series C6H5CH2CH2F (I), C6H5CH2CHF2 (II), C6H5CH2CF3 (III), and C6H5CH2CF2CF3 (V).Rates and activation parameters 3 (M-1 s-1)(50 deg C), ΔH* (kcal mol-1), and ΔS*, (eu)> are respectively: (a) using potassium tert-butoxide in tert-butyl alcohol, I (1.88 * 10-4, 19.1, -16.8), II (1.18 * 10-3, 20.3, -9.3), III (2.15 * 10-3, 22.1, -2.4), V (3.93 * 10-2, 16.9, -12.7); and (b) using sodium ethoxide in ethanol, I (1.32 * 10-6, 25.6, -6.5), II (5.28 * 10-7, 29.7, 3.0), III (3.45 * 10-7, 32.6, 12.5), V (5.41 * 10-5, 27.7, 7.6).The variation in tert-butoxide:ethoxide ratios of 140 (I), 2200 (II), 6200 (III), and 730 (V) are discussed in terms of a two-step mechanism with varying amounts of internal return for II, III, and V.Differences in reactivity for groups attached to the benzylic carbon (-CF3, -CF2Cl, -CHF2, -CF2CF3) and variation of ΔS* values for these reactions are also discussed in terms of a two-step mechanism.