2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane

Base Information

Chemical Name:2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane
CAS No.:1374335-00-8
Molecular Formula:C₂₆H₂₄N₂O₃
Molecular Weight:412.488
Hs Code.:

Synonyms:2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane

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Chemical Property of 2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane

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Technology Process of 2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane

There total 6 articles about 2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1374334-99-2
2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene

: 1374335-00-8
2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 50 ℃; for 24h;
DOI:10.1002/ejoc.201100781

Reference yield:

: 302589-19-1
2-(4-benzyloxy-benzylidene)-malonic acid dimethyl ester

: 1374335-00-8
2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethanol / 96 h / 0 °C

1.2: pH 3

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 25 °C

3.1: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C

4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 72 h / -10 - 25 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 50 °C

With oxalyl dichloride; palladium 10% on activated carbon; hydrogen; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1002/ejoc.201100781

Reference yield:

: 1389310-83-1
4-benzyloxybenzylidenemalonyl chloride

: 1374335-00-8
2-(4-hydroxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]-ethane

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C

2: methanesulfonyl chloride; triethylamine / dichloromethane / 72 h / -10 - 25 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 50 °C

With palladium 10% on activated carbon; hydrogen; methanesulfonyl chloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1002/ejoc.201100781