2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene

Base Information

Chemical Name:2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene
CAS No.:1374334-99-2
Molecular Formula:C₃₃H₂₈N₂O₃
Molecular Weight:500.597
Hs Code.:

Synonyms:2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene

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Chemical Property of 2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene

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Technology Process of 2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene

There total 5 articles about 2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1374334-98-1
(R,R)-2-(4-benzyloxybenzylidene)-N,N'-bis(2-hydroxy-1-phenylethyl)malonamide

: 1374334-99-2
2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at -10 - 25 ℃; for 72h;
DOI:10.1002/ejoc.201100781

Reference yield:

: 1389310-83-1
4-benzyloxybenzylidenemalonyl chloride

: 1374334-99-2
2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C

2: methanesulfonyl chloride; triethylamine / dichloromethane / 72 h / -10 - 25 °C

With methanesulfonyl chloride; triethylamine; In dichloromethane;
DOI:10.1002/ejoc.201100781

Reference yield:

: 302589-19-1
2-(4-benzyloxy-benzylidene)-malonic acid dimethyl ester

: 1374334-99-2
2-(4-benzyloxyphenyl)-1,1-bis[(R)-4,5-dihydro-4-phenyloxazoline-2-yl]ethene

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol / 96 h / 0 °C

1.2: pH 3

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 25 °C

3.1: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C

4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 72 h / -10 - 25 °C

With oxalyl dichloride; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1002/ejoc.201100781