5-(1-cyclohexenyl)-pentanophenone

Base Information

• Chemical Name: 5-(1-cyclohexenyl)-pentanophenone
• CAS No.: 389607-99-2
• Molecular Formula: C₁₇H₂₂O
• Molecular Weight: 242.361
• Mol file: 389607-99-2.mol

Synonyms:5-(1-cyclohexenyl)-pentanophenone

Chemical Property of 5-(1-cyclohexenyl)-pentanophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-(1-cyclohexenyl)-pentanophenone

There total 12 articles about 5-(1-cyclohexenyl)-pentanophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

5-(1-cyclohexenyl)-pentanophenone N,N-dimethylhydrazone (389607-98-1) → 5-(1-cyclohexenyl)-pentanophenone (389607-99-2)

Guidance literature:

With Amberlyst 15; In acetone; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(01)00817-1

Reference yield:

2-(1-Cyclohexenyl)ethanol (3197-68-0) → 5-(1-cyclohexenyl)-pentanophenone (389607-99-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 71 percent / pyridine / 24 h / 0 - 5 °C

2: 54 percent / NaI / acetone / 24 h / Heating

3: 94 percent / NaCN / 72 h / 80 °C

4: 84 percent / KOH / ethanol; H₂O / 18 h / 80 - 90 °C

5: 98 percent / LiAlH₄ / diethyl ether / 18 h / 20 °C

6: 73 percent / pyridine / 48 h / 0 °C

7: 81 percent / NaI / acetone / 24 h / Heating

8: 65 percent / LDA / tetrahydrofuran / 24 h / 0 - 20 °C

9: 69 percent / Amberlyst 15 / acetone / 24 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; Amberlyst 15; sodium cyanide; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; pyridine; diethyl ether; ethanol; water; acetone;

DOI:10.1016/S0040-4020(01)00817-1

Reference yield:

methyl 1-cyclohexene-1-acetate (53723-52-7) → 5-(1-cyclohexenyl)-pentanophenone (389607-99-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 62 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

2: 71 percent / pyridine / 24 h / 0 - 5 °C

3: 54 percent / NaI / acetone / 24 h / Heating

4: 94 percent / NaCN / 72 h / 80 °C

5: 84 percent / KOH / ethanol; H₂O / 18 h / 80 - 90 °C

6: 98 percent / LiAlH₄ / diethyl ether / 18 h / 20 °C

7: 73 percent / pyridine / 48 h / 0 °C

8: 81 percent / NaI / acetone / 24 h / Heating

9: 65 percent / LDA / tetrahydrofuran / 24 h / 0 - 20 °C

10: 69 percent / Amberlyst 15 / acetone / 24 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; Amberlyst 15; sodium cyanide; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; pyridine; diethyl ether; ethanol; water; acetone;

DOI:10.1016/S0040-4020(01)00817-1

upstream raw materials:

5-(1-cyclohexenyl)-pentanophenone N,N-dimethylhydrazone

2-(1-Cyclohexenyl)ethanol

methyl 1-cyclohexene-1-acetate

2-phenylethanol

Refernces