3197-68-0Relevant articles and documents
One-Pot Synthesis of Substituted Homoallylic Alcohols (3-Alkenols) and 1,1-Dideuterio-3-alkenols
Barluenga, Jose,Alvarez, Flora,Concellon, Jose M.,Yus, Miguel
, p. 654 - 655 (1986)
The reaction of the lithium enolate of ethyl acetate with various α-chlorocarbonyl compounds followed by in situ reduction with lithium aluminium hydride or deuteride and then lithiation with lithium powder leads, after hydrolysis, to homoallylic alcohols in a regioselective manner.
Spiro-compound, and preparation method and application thereof
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Paragraph 0108; 0109; 0110; 0111; 0112; 0113; 0114; 0115, (2017/02/17)
The invention relates to the fields of medicinal chemistry and pharmacotherapeutics, and discloses a spiro-compound as shown in the following general formula, and a preparation method and application thereof. A bioactivity screening result shows that the
Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: Discovery of deleobuvir (BI 207127)
LaPlante, Steven R.,B?s, Michael,Brochu, Christian,Chabot, Catherine,Coulombe, René,Gillard, James R.,Jakalian, Araz,Poirier, Martin,Rancourt, Jean,Stammers, Timothy,Thavonekham, Bounkham,Beaulieu, Pierre L.,Kukolj, George,Tsantrizos, Youla S.
, p. 1845 - 1854 (2014/04/03)
Conformational restrictions of flexible torsion angles were used to guide the identification of new chemotypes of HCV NS5B inhibitors. Sites for rigidification were based on an acquired conformational understanding of compound binding requirements and the roles of substituents in the free and bound states. Chemical bioisosteres of amide bonds were explored to improve cell-based potency. Examples are shown, including the design concept that led to the discovery of the phase III clinical candidate deleobuvir (BI 207127). The structure-based strategies employed have general utility in drug design.
