2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole
CAS No.:1262106-94-4
Molecular Formula:C₂₃H₁₉ClF₃N₃O₃
Molecular Weight:477.87
Hs Code.:

Synonyms:2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

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Chemical Property of 2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

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Technology Process of 2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

There total 2 articles about 2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 949166-97-6
5-chloro-2-(3,4,5-trifluorophenyl)pentanoic acid

: 1262106-83-1
3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride

: 1262106-94-4
2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: 5-chloro-2-(3,4,5-trifluorophenyl)pentanoic acid; 3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)benzohydrazide hydrochloride; With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

With tetrachloromethane; triphenylphosphine; In acetonitrile; for 3h; Reflux;

Reference yield:

: 209991-62-8
2-(3,4,5-trifluorophenyl)acetic acid

: 1262106-94-4
2-[4-chloro-1-(3,4,5-trifluorophenyl)butyl]-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Cooling with ice

1.2: 16 h / 20 °C

2.1: triethylamine; diethyl cyanophosphonate / N,N-dimethyl-formamide / 14 h / 20 °C

2.2: 3 h / Reflux

With n-butyllithium; diethyl cyanophosphonate; triethylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;