(4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone

Base Information

Chemical Name:(4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone
CAS No.:162439-39-6
Molecular Formula:C₂₉H₃₇NO₆
Molecular Weight:495.616
Hs Code.:

Synonyms:(4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone

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Chemical Property of (4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone

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Technology Process of (4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone

There total 5 articles about (4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 629-11-8
1,6-hexanediol

: 162439-39-6
(4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, 3.) pyridinium dichromate

2: 90 percent / oxalyl chloride, DMF / CH₂Cl₂ / 0 - 20 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, from -78 deg C to RT

4: 1.) diisopropylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C to RT

With dipyridinium dichromate; n-butyllithium; oxalyl dichloride; sodium hydride; diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00014a010

Reference yield:

: 100-39-0
benzyl bromide

: 162439-39-6
(4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, 3.) pyridinium dichromate

2: 90 percent / oxalyl chloride, DMF / CH₂Cl₂ / 0 - 20 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, from -78 deg C to RT

4: 1.) diisopropylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C to RT

With dipyridinium dichromate; n-butyllithium; oxalyl dichloride; sodium hydride; diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00014a010

Reference yield:

: 130892-97-6
6-benzyloxyhexanoic acid

: 162439-39-6
(4S)-4-benzyl-3-<(2'R)-2'-<(tert-butoxycarbonyl)methyl>-6'-(phenylmethoxy)hexanoyl>-2-oxazolidone

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / oxalyl chloride, DMF / CH₂Cl₂ / 0 - 20 °C

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 25 min, 2.) THF, hexane, from -78 deg C to RT

3: 1.) diisopropylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C to RT

With n-butyllithium; oxalyl dichloride; diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00014a010