methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate

Base Information

Chemical Name:methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate
CAS No.:736137-93-2
Molecular Formula:C₃₁H₃₆N₂O₉S
Molecular Weight:612.701
Hs Code.:

Synonyms:methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate

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Chemical Property of methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate

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Technology Process of methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate

There total 1 articles about methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 736137-92-1
4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene

: 736137-93-2
methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate

Guidance literature:: 4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene; With ozone; Sudan III; In methanol; dichloromethane; at -78 ℃;

With dimethylsulfide; In methanol; dichloromethane; at -78 - 25 ℃; for 3.5h;
DOI:10.1021/ja0472735

Reference yield: 96.0%

: 736137-93-2
methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate

: 736137-94-3
methyl 2-(5-amino-7-benzyloxy-6-methoxy-1-(p-toluenesulfonyl)indol-4-yl)acetate

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 25 ℃; for 0.5h;
DOI:10.1021/ja0472735 DOI:10.1021/ja064228j

Reference yield:

: 736137-93-2
methyl 2-(7-benzyloxy-5-((tert-butyloxy)carbonyl)amino-2-hydroxy-6-methoxy-1-(p-toluenesulfonyl)indolin-4-yl)acetate

: 736137-96-5
4-benzyloxy-5-methoxy-7-oxo-7,8-dihydro-6H-pyrrolo[3,2-e]indole

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / HCl / ethyl acetate / 0.5 h / 25 °C

2: 91 percent / AcOH / 24 h / 25 °C

3: 96 percent / Mg; methanol / 1.5 h / sonication

With hydrogenchloride; methanol; magnesium; acetic acid; In ethyl acetate;
DOI:10.1021/ja064228j