4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene

Base Information

Chemical Name:4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene
CAS No.:736137-92-1
Molecular Formula:C₃₁H₃₆N₂O₇S
Molecular Weight:580.702
Hs Code.:

Synonyms:4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene

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Chemical Property of 4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene

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Technology Process of 4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene

There total 12 articles about 4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 3588-30-5
2-methoxy-1,3-butadiene

: 736137-91-0
tert-butyl 3-benzyloxy-2-methoxy-4-(p-toluenesulfonyl)iminocyclohexa-2,5-dienylidenecarbamate

: 736137-92-1
4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene

Guidance literature:: 2-methoxy-1,3-butadiene; tert-butyl 3-benzyloxy-2-methoxy-4-(p-toluenesulfonyl)iminocyclohexa-2,5-dienylidenecarbamate; In tetrahydrofuran; at 40 ℃; for 48h;

With triethylamine; In dichloromethane; at 25 ℃; for 4h;
DOI:10.1021/ja0472735 DOI:10.1021/ja064228j

Reference yield:

: 20041-61-6
2-hydroxy-3-methoxy-4-nitrobenzaldehyde

: 736137-92-1
4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 88 percent / K₂CO₃ / dimethylformamide / 14 h / 25 °C

2.1: 97 percent / aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 12 h / 25 °C

3.1: diphenylphosphoryl azide; Et₃N / tetrahydrofuran / 3 h / 25 °C

3.2: 78 percent / H₂O / tetrahydrofuran / 2 h / Heating

4.1: 89 percent / pyridine / 5 h / 25 °C

5.1: 92 percent / SnCl₂*2H₂O / dioxane; ethanol / 0.5 h / Heating

6.1: 94 percent / tetrahydrofuran / 14 h / Heating

7.1: 96 percent / Pb(OAc)4 / CHCl₃ / 2 h / 25 °C

8.1: tetrahydrofuran / 48 h / 40 °C

8.2: 57 percent / Et₃N / CH₂Cl₂ / 4 h / 25 °C

With pyridine; lead(IV) acetate; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diphenylphosphoranyl azide; potassium carbonate; triethylamine; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; N,N-dimethyl-formamide; tert-butyl alcohol; 3.2: Curtius rearrangement / 8.1: Diels-Alder reaction;
DOI:10.1021/ja064228j

Reference yield:

: 736137-87-4
2-benzyloxy-3-methoxy-4-nitroaniline

: 736137-92-1
4-((tert-butyloxycarbonyl)amino)-2-benzyloxy-3,6-dimethoxy-1-((p-toluenesulfonyl)amino)-5,8-dihydronaphthalene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 89 percent / pyridine / 5 h / 25 °C

2.1: 92 percent / SnCl₂*2H₂O / dioxane; ethanol / 0.5 h / Heating

3.1: 94 percent / tetrahydrofuran / 14 h / Heating

4.1: 96 percent / Pb(OAc)4 / CHCl₃ / 2 h / 25 °C

5.1: tetrahydrofuran / 48 h / 40 °C

5.2: 57 percent / Et₃N / CH₂Cl₂ / 4 h / 25 °C

With pyridine; lead(IV) acetate; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; 5.1: Diels-Alder reaction;
DOI:10.1021/ja064228j