2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester
• CAS No.: 815601-33-3
• Molecular Formula: C₆₁H₁₂₀O₈Si₄
• Molecular Weight: 1093.96
• Mol file: 815601-33-3.mol

Synonyms:2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester

Chemical Property of 2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester

There total 5 articles about 2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,7R,11S,15S,18R)-3,7,11,15,19-Pentamethyl-icosane-1,3,7,11,15,18,19-heptaol (815601-29-7) → 2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester (815601-33-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; DMAP / CH₂Cl₂ / -78 °C

2: PPTs / dimethylformamide

3: 2,6-lutidine / CH₂Cl₂

With pyridine; 2,6-dimethylpyridine; dmap; pyridinium p-toluenesulfonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol048059o

Reference yield:

2,2-Dimethyl-propionic acid (3R,7R,11S,15S,18R)-3,7,11,15,18,19-hexahydroxy-3,7,11,15,19-pentamethyl-icosyl ester → 2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester (815601-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: PPTs / dimethylformamide

2: 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; pyridinium p-toluenesulfonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol048059o

Reference yield:

benzaldehyde dimethyl acetal (1125-88-8) → 2,2-Dimethyl-propionic acid (3R,7R,11S,15S)-17-((R)-5,5-dimethyl-2-phenyl-[1,3]dioxolan-4-yl)-3,7,11,15-tetramethyl-3,7,11,15-tetrakis-triethylsilanyloxy-heptadecyl ester (815601-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: PPTs / dimethylformamide

2: 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; pyridinium p-toluenesulfonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol048059o

upstream raw materials:

triethylsilyl chloride

(3R,7R,11S,15S,18R)-3,7,11,15,19-Pentamethyl-icosane-1,3,7,11,15,18,19-heptaol

benzaldehyde dimethyl acetal

pivaloyl chloride

Downstream raw materials:

(+)-glisoprenin A

((3R,7R,11S,15S)-3,7,11,15,19-Pentamethyl-3,7,11,15-tetrakis-triethylsilanyloxy-icos-18-ene-1-sulfonyl)-benzene

[(2E,6E,10E,14E)-(19R,23R,27S,31S)-1-(tert-Butyl-dimethyl-silanyloxy)-3,7,11,15,19,23,27,31,35-nonamethyl-19,23,27,31-tetrakis-triethylsilanyloxy-hexatriaconta-2,6,10,14,34-pentaene-17-sulfonyl]-benzene