Technology Process of N-(4-{2-[(2-cyano-3-fluorophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)-2-phenylacetamide
There total 7 articles about N-(4-{2-[(2-cyano-3-fluorophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)-2-phenylacetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
for 7h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / propan-1-ol / 4 h / Reflux
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
2.2: pH 10
3.1: potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 24 h / 20 °C
4.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 7 h / Inert atmosphere; Reflux
With
potassium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid;
bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine;
In
propan-1-ol; dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol; methanol / 2 h / 20 - 60 °C
2.1: potassium carbonate / triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / propan-1-ol / 4 h / Reflux
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3.2: pH 10
4.1: potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 24 h / 20 °C
5.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 7 h / Inert atmosphere; Reflux
With
hydroxylamine hydrochloride; potassium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine;
In
methanol; propan-1-ol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;