(S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

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Chemical Name:(S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate
CAS No.:1278520-75-4
Molecular Formula:C₃₆H₃₆ClN₃O₅
Molecular Weight:626.152
Hs Code.:

Synonyms:(S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

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Chemical Property of (S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

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Technology Process of (S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

There total 6 articles about (S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947-84-2
2-Biphenylcarboxylic acid

: 1278520-75-4
(S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 5 - 20 °C

2.1: chloro-trimethyl-silane; pyridine / toluene / 0.5 h / 5 °C

2.2: 2.5 h / 5 °C

2.3: 35 - 85 °C

3.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

3.2: 20 °C / Cooling with ice

4.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.2: pH 7 - 8

5.1: triethylamine / acetonitrile / 20 °C

With pyridine; hydrogenchloride; chloro-trimethyl-silane; thionyl chloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; acetic acid butyl ester; toluene; acetonitrile;

Reference yield:

: 4-[([1,1,-Biphenyl]-2-carbonyl)amino]-2-chlorobenzoic Acid

: 1278520-75-4
(S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

1.2: 20 °C / Cooling with ice

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.2: pH 7 - 8

3.1: triethylamine / acetonitrile / 20 °C

With hydrogenchloride; thionyl chloride; triethylamine; In 1,4-dioxane; acetic acid butyl ester; acetonitrile;

Reference yield:

: 886225-47-4
(S)-tert-butyl 3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxylate

: 1278520-75-4
(S)-tert-butyl 2-(1-(4-biphenyl-2-ylcarboxamido-2-chlorobenzoyl)-3-(hydroxymethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / acetic acid butyl ester / 1.5 h / 64 °C

1.2: 20 °C / Cooling with ice

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.2: pH 7 - 8

3.1: triethylamine / acetonitrile / 20 °C

With hydrogenchloride; thionyl chloride; triethylamine; In 1,4-dioxane; acetic acid butyl ester; acetonitrile;