2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

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Chemical Name:2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide
CAS No.:1301135-32-9
Molecular Formula:C₃₅H₂₉F₂N₇O
Molecular Weight:601.658
Hs Code.:

Synonyms:2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

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Chemical Property of 2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

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Technology Process of 2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

There total 6 articles about 2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14097-40-6
7-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 1301141-10-5
C₂₅H₁₆ClF₂N₅O

: 1301135-32-9
2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

Guidance literature:: 7-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline; C₂₅H₁₆ClF₂N₅O; With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 70 ℃; for 12h; Sealed vial;

With ammonium hydroxide; In water; acetonitrile;

Reference yield:

: 99365-69-2
7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1301135-32-9
2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; 1,2-dichloro-ethane / 0.17 h

1.2: 16 h / 90 °C

1.3: 1 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 20 °C / 1551.49 Torr

3.1: hydrogenchloride / isopropyl alcohol; 1,4-dioxane / 12 h / 70 °C / Sealed vial

With hydrogenchloride; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 14097-35-9
2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline

: 1301135-32-9
2,6-difluoro-N-methyl-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 20 °C / 1551.49 Torr

2: hydrogenchloride / isopropyl alcohol; 1,4-dioxane / 12 h / 70 °C / Sealed vial

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; ethyl acetate; isopropyl alcohol;