14097-35-9

Basic information

• Product Name: 2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 14097-35-9
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.2145
• Mol File: 14097-35-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 296.931°C at 760 mmHg
• Flash Point: 133.379°C
• Density: 1.208g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline(14097-35-9)
• EPA Substance Registry System: 2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline(14097-35-9)

Safety Data

• Hazardous Substances Data: 14097-35-9(Hazardous Substances Data)

Usage

General Description

2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline is a chemical compound that belongs to the class of tetrahydroisoquinoline derivatives. It has a molecular formula C10H11NO2 and a molecular weight of 177.2 g/mol. 2-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline is a nitro derivative of tetrahydroisoquinoline and contains a methyl group at the 2-position. It is a yellow crystalline solid that is primarily used as a research chemical in the study of neurotransmitters and their receptors. Its pharmacological properties and potential applications in drug development are also areas of interest for research and development.

Upstream product

• 24954-63-0 2,2,2-Trifluoro-N-(2-(4-nitrophenyl)ethyl)acetamide 
• 42923-79-5 7-nitro-1,2,3,4-tetrahydroisoquinoline 
• 50-00-0 formaldehyd 
• 99365-69-2 7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 64-18-6 formic acid 
• 108130-11-6 1-(2-chloro-ethyl)-2-chloromethyl-4-nitro-benzene 
• 74-89-5 methylamine 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 13058-73-6 7-nitroisoquinoline 
• 181514-37-4 2,2,2-trifluoro-1-(7-nitro-3,4-dihydroisoquinolin-2(1H)-yl)-ethan-1-one 

Downstream Products

• 14097-40-6 7-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 84017-98-1 N-(2-methyl-1,2,3,4-tetrahydro-[7]isoquinolyl)-benzamide 
• 1354553-74-4 5-pyridin-3-yl-thiophene-2-carboxylic acid 3-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzylamide 
• 1354554-87-2 4-[1,2,4]triazol-1-yl-benzoic acid 3-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzylamide 
• 1354555-44-4 [3-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester 
• 1354553-12-0 3'-hydroxy-biphenyl-4-carboxylic acid 3-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzylamide 
• 1301134-22-4 N-(3-(3-(2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)-N'-phenylurea 
• 1301134-19-9 2,6-difluoro-N-(3-(3-(2-(2-methyl-l,2,3,4-tetrahydroisoquinolin-7-ylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzamide 
• 1301138-49-7 C₂₇H₂₅N₇ 
• 1301138-48-6 C₂₇H₂₃N₇O₂ 

Relevant articles and documents

MACROCYCLIC COMPOUND SERVING AS WEE1 INHIBITOR AND APPLICATIONS THEREOF

Disclosed in the present invention are a macrocyclic compound serving as a Weel inhibitor, and applications thereof in the preparation of drugs for treating Weel-related diseases. The present invention specifically relates to a compound represented by for

BENZOTHIADIAZINE COMPOUNDS

The invention is directed to substituted benzothiadiazine derivatives. Specifically, the invention is directed to compounds according to Formula (I):wherein R, R1, R2, R3, R4 and R5 are as defined herein. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, autoimmune diseases, infections, atherosclerosis, and ischemia-reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

COMPOUNDS AND METHODS

Disclosed are compounds having the formula (I): wherein R1, R2, R3, R4, R5, and R6 are as defined herein, and methods of making and using the same.